AI Article Synopsis
- A study in Milan examined acute kidney injury (AKI) and the use of continuous renal replacement therapy (CRRT) in COVID-19 patients on mechanical ventilation, finding that 75% developed AKI and nearly 18% required CRRT.
- Most AKI cases were mild (stage 1), but there was a significant mortality risk, with 38.9% of the AKI patients and 52.9% of those receiving CRRT dying during their hospital stay.
- The research highlights that older patients and those with pre-existing chronic kidney disease (CKD) were more likely to develop AKI or need CRRT, indicating higher vulnerability in this group.
Article Abstract
Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems.
Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients.
Methods: Observational study in a tertiary care hospital in Milan, Italy.
Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients.
Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445373 | PMC |
| http://dx.doi.org/10.1159/000508657 | DOI Listing |
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