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Middle ear biofilm and sudden deafness - a light and transmission electron microscopy study.
Front Neurol
December 2024
Department of Surgical Sciences, Otorhinolaryngology and Head and Neck Surgery, Uppsala University, Uppsala, Sweden.
Background: There still exists controversy about whether the healthy human middle ear mucosa is sterile or if it may harbor a diverse microbiome. Considering the delicacy of the human round window membrane (RWM), different mechanisms may exist for avoiding inner ear pathogen invasion causing sensorineural deafness. We re-analyzed archival human RWMs using light and transmission electron microscopy after decalcification to determine if bacteria are present in clinically normal human middle ears.
View Article and Find Full Text PDFAnalysis of posterior hip joint impingement about developmental dysplasia of the hip after total hip arthroplasty.
Clin Biomech (Bristol)
December 2024
Department of Orthopedic Surgery, Hiroshima University Hospital Graduate School of Biomedical and Health Sciences, Hiroshima City, Hiroshima Prefecture, Japan.
Background: Total hip arthroplasty is the preferred treatment for advanced hip osteoarthritis, yet complications like hip dislocation (0.2 %-10 %) persist due to factors such as implant design, positioning, surgical technique, and patient-specific conditions. Impingement between prosthetic components or the acetabulum and proximal femur is a primary cause of instability.
View Article and Find Full Text PDFChanges in the Periodontal Gap After Long-Term Tooth Movement into Augmented Critical-Sized Defects in the Jaws of Beagle Dogs.
Dent J (Basel)
November 2024
Department of Orthodontics, Rostock University Medical Centre, Strempelstrasse 13, 18057 Rostock, Germany.
Extensive and closely coordinated remodeling processes take place in the periodontal ligament (PDL) and the adjacent bone during orthodontic tooth movement. In complex orthodontic cases, it is necessary to move teeth into an augmented bony defect, for example, in patients with cleft lip, alveolus, and palate. The important role of the PDL during tooth movement is well accepted but not fully understood.
View Article and Find Full Text PDFGuided Bone Regeneration in the Posterior Mandible Using a Resorbable Metal Magnesium Membrane and Fixation Screws: A Case Report.
Case Rep Dent
December 2024
Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorder, Charité-Universitätsmedizin Berlin, Aßmannshauser Straße 4-6 14197, Berlin, Germany.
Due to bone loss, implant placement in the posterior mandible is often impossible without prior augentative procedures. The reconstruction of bone defects with horizontal and vertical components using particulated bone grafts requires the placement of a mechanically stable structure for stabilization of the grafting material. Although titanium-reinforced membranes and titanium meshes have been shown to be effective in this indication, the necessity of their removal, often in a separate surgical procedure, is seen as a disadvantage.
View Article and Find Full Text PDF[Zebrafish Xenographs in Oncology and Personalized Medicine].
Mol Biol (Mosk)
December 2024
National Research Center Kurchatov Institute, Moscow, 123182 Russia.
The bony fish Danio rerio (zebrafish) has become one of the important vertebrate model organisms in biomedical cancer research and is used, among other things, for the development of anticancer drugs using xenotransplantation approaches. The ex utero development of zebrafish, optically transparent tissues in the first month of growth, and the immature adaptive immune system during this period greatly facilitate the manipulation of embryos. For highly aggressive cancers where patient survival may be expected to be only a few months, a zebrafish xenograft assay may be the only appropriate method as it requires only four to seven days.
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