AI Article Synopsis
- The article reviews studies on how host and viral genetics, particularly HLA gene variations, influence immune responses to coronaviruses and the resulting clinical outcomes.
- It covers seasonal coronaviruses, SARS-CoV, and MERS-CoV, before diving into the genetic variations linked to SARS-CoV-2 and COVID-19.
- The conclusion highlights existing research gaps and suggests directions for future studies to enhance understanding of SARS-CoV-2 immunology.
Article Abstract
This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and MERS-CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS-CoV-2 and COVID-19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS-CoV-2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404857 | PMC |
| http://dx.doi.org/10.1111/imr.12897 | DOI Listing |
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