Introduction: The Bethesda System recommends repeat fine needle aspiration (rFNA) as a management option for nodules classified under the non-diagnostic (ND) and atypia of undetermined significance (AUS/FLUS) categories. We evaluated the impact of an rFNA in diagnostic resolution and the role of early (≤3 months) vs delayed (more than 3 months) rFNA of nodules initially diagnosed as ND and AUS/FLUS.
Methods: We retrospectively collected all thyroid FNA performed in a 4-year period with repeat aspiration. For cases initially signed out as ND or AUS/FLUS, diagnostic resolution was defined as a change to a Bethesda System category other than these two on rFNA. Comparison and regression models were fitted to identify the impact of time of rFNA on diagnostic resolution.
Results: In total, 184 cases were initially assigned as ND and 143 as AUS/FLUS, with overall diagnostic resolution rates for the reassessment of these nodules calculated at 70.1% and 62.9%, respectively. For ND cases, time of rFNA was not significantly associated with diagnostic resolution (P > .05). For AUS/FLUS nodules, however, repeat aspiration performed in more than 3 months after the initial diagnosis was 2.5 times more likely to achieve a resolution in diagnosis than early rFNA (P = .024).
Conclusions: Repeat aspiration of ND and AUS/FLUS nodules helped define diagnosis for the majority of cases, being highly effective in determining correct patient management. For AUS/FLUS nodules, repeat aspiration performed more than 3 months after the initial diagnosis was associated with a higher diagnostic resolution.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/cyt.12887 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Proof-of-Concept Study of Ulipristal Acetate for Early Medication Abortion.
NEJM Evid
January 2025
Gynuity Health Projects, New York.
Background: The current regimen for early medication abortion in many countries is mifepristone and misoprostol, but mifepristone is relatively expensive and limited in many regions. Ulipristal acetate, with a similar chemical profile, might be an alternative. This proof-of-concept study evaluated ulipristal acetate and misoprostol for medication abortion through 63 days of gestation.
View Article and Find Full Text PDFComparison of core-needle biopsy and repeat fine-needle aspiration biopsy for thyroid nodules with initially inconclusive findings: a systematic review, diagnostic accuracy meta-analysis, and meta-regression.
J Am Soc Cytopathol
December 2024
Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia.
Introduction: The rate of nondiagnostic and indeterminate cytology findings from fine-needle aspiration biopsy (FNAB) is quite high, resulting in repeated puncture and unnecessary surgery. The primary objective of this investigation is to compare diagnostic accuracy of core-needle biopsy (CNB) with repeat FNAB for thyroid nodules with initially inconclusive (nondiagnostic and/or atypia of undetermined significance) FNAB results.
Materials And Methods: A thorough search was performed on the Cochrane Library, Scopus, Europe PMC, and Medline databases until October 20th, 2024, employing a combination of pertinent keywords.
High Rates of Unnecessary Surgery for Indeterminate Thyroid Nodules in the Absence of Molecular Test and the Cost-Effectiveness of Utilizing Molecular Test in an Asian Population: A Decision Analysis.
Thyroid
January 2025
Division of Endocrine Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong.
Cytologically indeterminate thyroid nodules (Bethesda class III or IV) carry a 10-40% risk of malignancy. Diagnostic lobectomies are frequently performed but negative surgeries incur unnecessary costs on the healthcare system, potential complications, and negative impacts on quality of life. Molecular tests (MTs) have been developed to reduce unnecessary surgeries.
View Article and Find Full Text PDFThe impact of anesthesia methods and rapid on-site evaluation on the diagnosis of lung cancer using endobronchial ultrasound-guided transbronchial needle aspiration: a retrospective study.
J Thorac Dis
December 2024
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a critical method for diagnosing lung cancer. While EBUS-TBNA is commonly performed under conscious sedation, the potential benefits of conducting the procedure under general anesthesia and incorporating rapid on-site evaluation (ROSE) to enhance diagnostic yield remain uncertain. This study aims to investigate the impact of anesthesia methods and ROSE on the diagnostic efficacy of EBUS-TBNA for lung cancer.
View Article and Find Full Text PDFRegrowth Rate of a Cardiac Myxoma After Percutaneous Aspiration.
JACC Case Rep
January 2025
Department of Cardiology, Lankenau Medical Center, Wynnewood, Pennsylvania, USA.
Cardiac myxomas are typically treated surgically; however, the operative mortality and recurrence rates are not negligible. In the current report we describe a case of repeat percutaneous aspiration of a right atrial myxoma. The report supports feasibility of the procedure, provides the asymptomatic timeframe after debulking, and the regrowth rate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!