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Spatial Distribution of Meningiomas: A Magnetic Resonance Image Atlas.
Neurosurgery
August 2024
Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Article Synopsis
- The study investigates the relationship between the location and size of meningiomas (a type of brain tumor) and their clinical and biological characteristics, noting that the anatomic origin can be difficult to determine in larger tumors.
- Researchers analyzed MRI scans and the World Health Organization (WHO) and molecularly Integrated Grades (IG) of meningiomas from adult patients to create a mapping atlas that correlates tumor location with grade.
- Results indicate that benign tumors tend to cluster around the midline anterior skull base, while malignant ones are more common in areas like the falcine/parasagittal region, suggesting that molecular classification may provide more specific insights than traditional grading.
Comparison of Isolated Lymphocyte and Whole Blood-Based CBMN Assays for Radiation Triage.
Cytogenet Genome Res
March 2024
Center for Radiological Research, Columbia University, New York, New York, USA.
Following a mass-casualty nuclear/radiological event, there will be an important need for rapid and accurate estimation of absorbed dose for biological triage. The cytokinesis-block micronucleus (CBMN) assay is an established and validated cytogenetic biomarker used to assess DNA damage in irradiated peripheral blood lymphocytes. Here, we describe an intercomparison experiment between two biodosimetry laboratories, located at Columbia University (CU) and Health Canada (HC) that performed different variants of the human blood CBMN assay to reconstruct dose in human blood, with CU performing the assay on isolated lymphocytes and using semi-automated scoring whereas HC used the more conventional whole blood assay.
View Article and Find Full Text PDFTools for Drawing Informative Idiograms.
Methods Mol Biol
June 2023
Department of Agronomy and Plant Breeding, University of Kurdistan, Sanandaj, Iran.
Each species has a typical karyotype, which represents the phenotypic appearance of the somatic chromosomes including number, size, and morphology. An idiogram is a diagrammatic representation of the chromosomes showing their relative size, homologous groups, and different cytogenetic landmarks. Chromosomal analysis of cytological preparations is an essential component of many investigations, which involves the calculation of karyotypic parameters and the generation of idiograms.
View Article and Find Full Text PDFEmbryo Culture Medium Has No Impact on Mosaicism Rates: a Sibling Oocyte Study.
Reprod Sci
November 2023
ART Fertility Clinics, Abu Dhabi, United Arab Emirates.
Human embryos cultured in vitro can contain two or more cytogenetically distinct cell lineages known as "chromosomal mosaicism". Since mosaicism is produced by mitotic errors after fertilization occurs, culture conditions might contribute to mosaicism origins. Many studies demonstrated that euploidy rates are not affected by culture media; however, whether oocytes cultured under continuous culture media (CCM) or sequential culture media (SCM) has a higher risk of mosaicism occurring remains unsolved.
View Article and Find Full Text PDFRENEB Inter-Laboratory Comparison 2021: The Cytokinesis-Block Micronucleus Assay.
Radiat Res
June 2023
Faculty of Medicine and Health Sciences, Radiobiology Research Unit, Universiteit Gent, Gent, Belgium.
The goal of the RENEB inter-laboratory comparison 2021 exercise was to simulate a large-scale radiation accident involving a network of biodosimetry labs. Labs were required to perform their analyses using different biodosimetric assays in triage mode scoring and to rapidly report estimated radiation doses to the organizing institution. This article reports the results obtained with the cytokinesis-block micronucleus assay.
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