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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330511 | PMC |
| http://dx.doi.org/10.18683/germs.2020.1195 | DOI Listing |
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From the INVICTUS Trial to Current Considerations: It's Not Time to Retire Vitamin K Inhibitors Yet!
Pharmaceuticals (Basel)
October 2024
Division of Cardiology and CardioLab, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Article Synopsis
- Atrial fibrillation (AF) is common and usually treated with oral anticoagulants to prevent strokes, where direct oral anticoagulants (DOAC) are more effective in reducing certain types of bleeding compared to vitamin K antagonists (VKA).
- The INVICTUS study showed that the DOAC rivaroxaban was not superior to VKA in preventing serious complications like stroke for patients with rheumatic valvular AF, leading to higher death and drug discontinuation rates in the DOAC group.
- While VKAs remain the standard treatment for patients with moderate-to-severe mitral stenosis and prosthetic valves, new factor XI inhibitors show promise in reducing bleeding risks and are currently undergoing further testing in AF and
Native Valve Legionella Endocarditis in a 74-Year-Old Male: A Case Report and Review.
Cureus
October 2024
Internal Medicine, Ascension St. John Hospital, Warren, USA.
Legionella is a bacterium that primarily causes respiratory infections. Rarely, it can result in extrapulmonary infections like endocarditis. We present a case of native valve endocarditis caused by Legionella in a 74-year-old male.
View Article and Find Full Text PDFVisual grading of valvular regurgitation is inferior to measurement - results from the VIAVA-study (VIsual Assessment of VAlvular Regurgitation).
Echo Res Pract
November 2024
Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Müllner Hauptstraße 48, Salzburg, 5020, Austria.
While the visual estimation of systolic left ventricular function by experienced examiners closely aligns with quantitative methodologies, the accuracy of visual estimation in determining the severity of valvular regurgitation using colour flow Doppler assessment of native heart valves remains largely unexplored. This study analysed the ability of 262 physicians to visually estimate the severity of 12 native valve regurgitations by grading colour Doppler transthoracic echocardiography loops in an online questionnaire. The assessments of the participants were compared to standardized quantitative evaluations conducted by certified echocardiography experts.
View Article and Find Full Text PDFA man in his 60s presented to the emergency department with central crushing chest pain on a background of a week's history of flu-like symptoms. An ECG demonstrated ischaemia with blood tests confirming myocardial injury; catheter angiography revealed an obstructed diagonal coronary artery. In addition, blood tests revealed elevated markers of inflammation, blood cultures grew and transthoracic echocardiography demonstrated a mitral valve lesion.
View Article and Find Full Text PDFInfective Endocarditis Caused by Streptococcus sinensis: A Rare but Fatal Infection.
Cureus
September 2024
Microbiology, Mater Dei Hospital, L-Imsida, MLT.
Article Synopsis
- A 65-year-old man with no significant health issues was diagnosed with infective endocarditis after experiencing symptoms for four months, including elevated inflammatory markers and worsening kidney function.
- Tests confirmed that the infection affected both the aortic and mitral valves and was caused by a rare viridans group bacteria, making this case quite unusual.
- The patient underwent anti-microbial treatment and surgery to replace the infected valves but tragically died two weeks later due to complications from ventilator-associated pneumonia, despite receiving intensive care.
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