Association of Genetic Polymorphisms in with the Progression of Genetic Susceptibility to Gastric Cancer.

Objective: To investigate the relationship between polymorphism of gene and and susceptibility to gastric cancer.

Methods: A case-control study was conducted to select 577 cases of primary gastric cancer and 678 cases of normal control. We extracted whole blood genomic DNA and amplified the target gene fragment by PCR. The genotyping and allele were tested through the snapshot method.

Results: In this case-control study, we observed that there was a difference in the genotype distribution of gene between the case group and the control group. The frequency distribution of TC heterozygous mutation in the case group was higher than that in the control group. The smoking rate in the case group (34.49%) was higher than that in the control group (27.29%), and the difference in frequency distribution between the two groups was statistically significant (=0.006). Our findings suggest that is associated with susceptibility to GC, which is more evident among elderly patients (>62 years), nonsmokers, and patients who do not consume alcohol. The analysis of the relationship between the gene site variant and clinical factors of gastric cancer showed that, compared with the tumor size <2 cm group, patients with tumor size ≥2 cm and whom carrying site mutations had a higher frequency distribution, and the difference was statistically significant (=0.022). Compared with the nonhyperglycemic group, the frequency distribution of patients with site mutations in the diabetes group was higher, and the difference was statistically significant ( < 0.001).

Conclusion: This study shows that there is a correlation between smoking and the occurrence of gastric cancer. Based on our research, the functional SNP TC genotype may be an indicator of individual susceptibility to GC. The mutation at may be related to the size of gastric cancer. The mutation rate of of gene is higher in diabetic gastric cancer patients.