This work proposes a model that takes into account the anisotropy of material with its inhomogeneity and geometrical and material nonlinearities. According to Newton's second law, the investigations were carried out on the simultaneous effects of mechanical load and thermal treatment on the Tournemire argillite material. The finite difference method was used for the numerical resolution of the problem by the MATLAB 2015a software in order to determine the peak stress and strain of argillite as a function of material nonlinearity and demonstrated the inhomogeneity parameter Ω. The critical temperature from which the material damage was pronounced is 500°C. Indeed, above this temperature, the loss of rigidity of argillite reduced significantly the mechanical performance of this rock. Therefore, after 2.9 min, the stress reduction in or direction was 75.5% with a peak stress value of 2500 MPa, whereas in direction, the stress reduction was 74.1% with a peak stress value of 1998 MPa. Meanwhile, knowing that the material inhomogeneity was between 2995 and 3256.010, there was an increase in peak stress of about 75%. However, the influence of the material nonlinearity was almost negligible. Thus, the geometrical nonlinearity allows having the maximal constant strain of about 1.25 in the direction of the applied dynamic mechanical force.
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http://dx.doi.org/10.1155/2020/2978257 | DOI Listing |
Sci Rep
January 2025
University of Ulsan, 93 Daehak-ro, Nam-gu, Ulsan, 680-749, Republic of Korea.
This study employed large eddy simulation (LES) with the wall-adapting local eddy-viscosity (WALE) model to investigate transitional flow characteristics in an idealized model of a healthy thoracic aorta. The OpenFOAM solver pimpleFoam was used to simulate blood flow as an incompressible Newtonian fluid, with the aortic walls treated as rigid boundaries. Simulations were conducted for 30 cardiac cycles and ensemble averaging was employed to ensure statistically reliable results.
View Article and Find Full Text PDFArch Biochem Biophys
January 2025
Department of Critical Care Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China; Heilongjiang Provincial Key Laboratory of Critical Care Medicine, Harbin 150001, China; Central Laboratory of The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. Electronic address:
Background: Ischemia-reperfusion injury (IRI) often results in renal impairment. While the presence of neutrophil extracellular traps (NETs) is consistently observed, their specific impact on IRI is not yet defined. Sivelestat sodium, an inhibitor of neutrophil elastase which is crucial for NET formation, may offer a therapeutic approach to renal IRI, warranting further research.
View Article and Find Full Text PDFPharmaceutics
January 2025
NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China.
Background: The Epstein-Barr virus (EBV) is intricately linked to a range of human malignancies, with EBV latent membrane protein 2A (LMP2A) emerging as a potential target antigen for immunotherapeutic strategies in the treatment of nasopharyngeal carcinoma (NPC).
Methods: The modified vaccinia virus Ankara (MVA) is universally used in vector vaccine research because of its excellent safety profile and highly efficient recombinant gene expression. Here, we constructed a novel MVA-LMP2A recombinant virus and investigated its specific immune response induction and oncolytic effect.
Materials (Basel)
January 2025
Department of Architecture and Civil Engineering, City University of Hong Kong, Hong Kong.
This paper investigates the effects of particle morphology (PM) and particle size distribution (PSD) on the micro-macro mechanical behaviours of granular soils through a novel X-ray micro-computed tomography (μCT)-based discrete element method (DEM) technique. This technique contains the grain-scale property extraction by the X-ray μCT, DEM parameter calibration by the one-to-one mapping technique, and the massive derivative DEM simulations. In total, 25 DEM samples were generated with a consideration of six PSDs and four PMs.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Department of Civil Engineering, Laval University, Québec City, QC G1V 0A6, Canada.
Despite decades of extensive studies, the mechanism of concrete creep remains a subject of debate, mainly due to the complex nature of cement microstructure. This complexity is further amplified by the interplay between water and the cement microstructure. The present study aimed to better understand the creep mechanism through creep tests on microprisms of cement paste at hygral equilibrium.
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