AI Article Synopsis
- The study investigates the long-term impact of lymphoma treatment on kidney health, specifically focusing on chronic kidney disease (CKD) in lymphoma survivors.
- It analyzed data from 397 patients, noting significant rates of CKD development over time, with 31% of patients diagnosed with CKD within 10 years of their lymphoma treatment.
- Key risk factors for developing CKD included age, hypertension, hyperuricemia, and diabetes, highlighting a critical need for ongoing monitoring of kidney function in these survivors.
Article Abstract
With improving lymphoma survival, late effects of therapy have emerged. Here, we describe pattern of long-term chronic kidney disease (CKD) in lymphoma survivors. Demographics, comorbidities, lymphoma histology, treatment, and outcome were recorded. Glomerular filtration rate (GFR) was recorded at diagnosis, 1, 2, 5, and 10 years. Rate of GFR decline with time and CKD-free survival were recorded. In 397 patients, median age was 55.3 (18-88), 54% were male, 60% were African Americans, 42% had hypertension (HTN), 15% had DM, 13% had hyperuricemia, 86% received chemotherapy, and 14% had baseline CKD. Total 125 (31%) patients developed CKD in 10 years after lymphoma diagnosis. Probability of CKD development increased significantly with time (23% at 1 year to 41% at 10 years). Rate of GFR decline was 4.6 mL/min/per year. Age, HTN, hyperuricemia, and DM (in young patients) predicted risk of CKD. Thus, lymphoma survivors are at substantial long-term risk of CKD development.
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| http://dx.doi.org/10.1080/10428194.2020.1786555 | DOI Listing |
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