AI Article Synopsis
- The study investigates the effects of different anaesthetic combinations on common marmosets, focusing on alfaxalone alone and in combination with ketamine and butorphanol-medetomidine.
- Seven female marmosets were treated with four different anaesthetic protocols, with varying durations of unresponsiveness observed after administration.
- The results indicate that the combination treatment (AMB) caused a more significant decrease in heart rate and oxygen levels, suggesting the need for careful monitoring and oxygen support when using this protocol.
Article Abstract
Background: Anaesthesia is often required in common marmosets undergoing various procedures. The aim of this study was to evaluate anaesthetic and cardiopulmonary effects of alfaxalone, alfaxalone-ketamine and alfaxalone-butorphanol-medetomidine in common marmosets.
Methods: The following treatments were repeatedly administered to seven female common marmosets: Treatment A, alfaxalone (12 mg kg ) alone; treatment AK, alfaxalone (1 mg animal ) plus ketamine (2.5 mg animal ); treatment AMB, alfaxalone (4 mg kg ), medetomidine (50 µg kg ) plus butorphanol (0.3 mg kg ); and treatment AMB-Ati, AMB with atipamezole at 45 minutes.
Results And Conclusions: Marmosets became laterally recumbent and unresponsive for approximately 30 minutes in A and AK and for approximately 60 minutes in AMB. The animals showed rapid recovery following atipamezole injection in AMB-Ati. The decrease in heart rate and SpO was significantly greater in AMB compared to A and AK. Oxygen supplementation, anaesthetic monitors and atipamezole should be available especially when AMB is administered.
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| http://dx.doi.org/10.1111/jmp.12482 | DOI Listing |
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