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Clear cell hidradenoma of the male breast: A case report and literature review.
Int J Surg Case Rep
January 2025
Department of Pathology, The First Affiliated Hospital of Zhejiang University School of Medicine, No.79 Qingchun Road, Hangzhou, Zhejiang 310003, China. Electronic address:
Introduction: Clear cell hidradenoma (CCH) is a rare type of benign breast tumor that may undergo malignant transformation in a few cases. It clinically manifests as a painless breast mass, and may include nipple discharge. Complete surgical excision with adequate safety margins is the primary treatment.
View Article and Find Full Text PDFNKX3.1 Helps Distinguish Hyalinizing Clear Cell Carcinoma From Other Clear Cell Salivary Gland Neoplasms.
Lab Invest
November 2024
Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan. Electronic address:
Hyalinized clear cell carcinoma (HCCC) is a rare tumor of the minor salivary gland, characterized by pale cytoplasm and EWSR1::ATF1 fusion. Recently, new fusions, such as EWSR1::LARP4 and SMARCA2::CREM, have also been identified. Histologically, HCCC closely resembles other salivary gland tumors like mucoepidermoid carcinoma and myoepithelial carcinoma, and there are no specific immunohistological markers for its identification.
View Article and Find Full Text PDFNanoString nCounter-Based Assay for Detection of Fusion-Associated Salivary Gland Tumors.
Head Neck Pathol
October 2024
Department of Pathology, University of British Columbia, Vancouver, BC, Canada.
Purpose: Salivary gland tumors include numerous subtypes that vary from benign to highly aggressive, with many showing overlapping histopathological features that can make diagnosis challenging. Most subtypes express driver fusion genes that are tumor specific, and detection of such fusions is useful for differentiating amongst specific diagnoses, determining appropriate tumor grading, and guiding effective treatment. Currently, fusions can be detected by FISH, RT-PCR or through next-generation sequencing approaches, all of which are highly effective methodologies but can be costly or time consuming.
View Article and Find Full Text PDFManaging malignant sublingual gland tumors: a single institution experience with 23 patients.
BMC Cancer
September 2024
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan City, 430079, China.
Article Synopsis
- Malignant tumors of the sublingual gland are rare and challenging to diagnose and treat, highlighting the need for better understanding of their pathology, characteristics, and management strategies.
- This study reviewed 23 cases of sublingual gland malignancies, identifying adenoid cystic carcinoma and mucoepidermoid carcinoma as the most common types and emphasizing the importance of early diagnosis and surgical intervention for favorable outcomes.
- Surgical excision is the primary treatment approach, often accompanied by radiotherapy for advanced cases, and reconstruction techniques are employed to address significant tissue defects in the mouth.
A Retrospective Cytomorphologic Analysis of Salivary Gland Fine Needle Aspirates Classified as Salivary Gland Neoplasm of Uncertain Malignant Potential: A 6-year Institutional Experience.
Diagn Cytopathol
December 2024
Mayo Clinic, Jacksonville, Florida, USA.
Article Synopsis
- - The Milan System for Reporting Salivary Gland Cytopathology is used to evaluate salivary gland fine needle aspirations (FNAs) and classifies uncertain malignant potential (SUMP) lesions that are neoplastic but not clearly benign or malignant.
- - A retrospective review of 36 SUMP cases over six years at one institution revealed that 31 had surgical follow-ups, with 22 benign and 9 malignant diagnoses; the overall risk of neoplasm was 93.5% and malignancy risk was 29%.
- - The study suggests subclassifying SUMP lesions into categories based on cytomorphologic features, which can help improve diagnosis and risk assessment in these uncertain cases.
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