AI Article Synopsis
- Community-acquired bacterial pneumonia (CABP) is commonly treated in outpatient settings, and delafloxacin is an approved treatment option for adults with CABP.
- A budget impact model was created to assess the financial implications of including delafloxacin in treatment plans from a payer's viewpoint, using various clinical and cost data.
- The analysis showed a total budget impact of about $58,987 for 1 million members, mainly due to acquisition costs, and a smaller impact of $5,042 for patients with COPD/asthma, indicating a conservative financial outlook for incorporating delafloxacin into treatment formularies.
Article Abstract
Background And Objective: Community-acquired bacterial pneumonia (CABP) affects millions of people each year in the USA. The majority of patients with CABP are treated in the community setting with empirical antimicrobial therapy. Delafloxacin is an anionic fluoroquinolone approved for the treatment of adult patients with CABP. This de novo analysis sought to estimate the budget impact of delafloxacin in the treatment of adult patients with CABP in the outpatient setting from the payer's perspective.
Methods: A budget impact model (BIM) was developed from the perspective of a US third-party payer to estimate the cost of introducing delafloxacin for the outpatient treatment of CABP over a 1-year time horizon. Population, clinical, and cost inputs were based on the available literature, clinical trial data, and real-world evidence studies. Scenario analyses were conducted to evaluate the potential budget impact among COPD/asthma patients based on the findings from the phase III trial of delafloxacin for CABP, which indicated that patients with COPD or asthma may experience improved effectiveness with delafloxacin compared to moxifloxacin.
Results: In the base-case analysis, with a hypothetical plan of 1,000,000 members, the model estimated that adding delafloxacin to the formulary resulted in a total budget impact of $58,987. This increase was mainly attributed to treatment acquisition costs. In the scenario analysis that was restricted to COPD/asthma patients, adding delafloxacin to the formulary was estimated to result in a total budget impact of $5,042.
Conclusion: The results of the budget impact analyses provide conservative estimates of the impact of adding delafloxacin to outpatient formularies in substitution of moxifloxacin.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511275 | PMC |
| http://dx.doi.org/10.1007/s40261-020-00938-y | DOI Listing |
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