AI Article Synopsis
- CCN3 is a matricellular protein that helps in the differentiation of oligodendrocyte progenitor cells and myelination, making it significant for central nervous system (CNS) repair and maintenance.
- CCN3 is primarily expressed by neurons in various regions of the CNS, including the cerebral cortex and spinal cord, and its levels increase temporarily after demyelination.
- Despite its expression in the CNS, studies show that CCN3 is not essential for the formation of oligodendrocytes or the process of myelination/remyelination in live mice.
Article Abstract
CCN3 is a matricellular protein that promotes oligodendrocyte progenitor cell differentiation and myelination in vitro and ex vivo. CCN3 is therefore a candidate of interest in central nervous system (CNS) myelination and remyelination, and we sought to investigate the expression and role of CCN3 during these processes. We found CCN3 to be expressed predominantly by neurons in distinct areas of the CNS, primarily the cerebral cortex, hippocampus, amygdala, suprachiasmatic nuclei, anterior olfactory nuclei, and spinal cord gray matter. CCN3 was transiently up-regulated following demyelination in the brain of cuprizone-fed mice and spinal cord lesions of mice injected with lysolecithin. However, CCN3 mice did not exhibit significantly different numbers of oligodendroglia or differentiated oligodendrocytes in the healthy or remyelinating CNS, compared to WT controls. These results suggest that despite robust and dynamic expression in the CNS, CCN3 is not required for efficient myelination or remyelination in the murine CNS in vivo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395501 | PMC |
| http://dx.doi.org/10.1073/pnas.1922089117 | DOI Listing |
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