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The role of physical exercise in cancer therapy-related CV toxicity.
Future Cardiol
January 2025
Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Benefits of nostalgic landmarks for people living with Alzheimer's disease.
J Alzheimers Dis
December 2024
School of Social Sciences, University of the West of England, Bristol, UK.
Background: Emerging literature shows that nostalgia induced by autobiographical reflection and music confers psychological benefits to people living with dementia.
Objective: Our objective was to test the potential benefits of nostalgic landmarks for people living with Alzheimer's disease.
Methods: We displayed the landmarks as wall-mounted pictures within a virtual environment.
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy.
Nat Rev Cancer
November 2024
Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Over the past decade, genome-scale molecular profiling of large childhood cancer survivorship cohorts has led to unprecedented advances in our understanding of the genetic and epigenetic bases of therapy-related adverse health outcomes in this vulnerable population. To facilitate the integration of knowledge generated from these studies into formulating next-generation precision care for survivors of childhood cancer, we summarize key findings of genetic and epigenetic association studies of long-term therapy-related adverse effects including subsequent neoplasms and cardiomyopathies among others. We also discuss therapy-related genotoxicities including clonal haematopoiesis and DNA methylation, which may underlie accelerated molecular ageing.
View Article and Find Full Text PDFHealth Knowledge in Adolescent Childhood Cancer Survivors at High Risk for Therapy-Related Cardiotoxicity.
J Adolesc Young Adult Oncol
November 2024
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Childhood cancer survivors' (CCS) knowledge about late effects can promote positive health behaviors and autonomy. Cardiotoxicity is a major source of morbidity, which can be mitigated through exercise. Descriptive and Fisher's exact statistics were used to characterize health knowledge and physical activity in CCS ≥13 years at high risk for cardiotoxicity.
View Article and Find Full Text PDFPediatric Central Nervous System Embryonal Tumors: Presentation, Diagnosis, Therapeutic Strategies, and Survivorship-A Review.
Pediatr Neurol
December 2024
Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington; Division of Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington; Fred Hutch Cancer Center, Seattle, Washington.
Central nervous system (CNS) embryonal tumors represent a diverse group of neoplasms and have a peak incidence in early childhood. These tumors can be located anywhere within the CNS, and presenting symptoms typically represent tumor location. These tumors display distinctive findings on neuroimaging and are staged using magnetic resonance imaging of the brain and spine as well as evaluation of cerebrospinal fluid.
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