AI Article Synopsis
- A meta-analysis was conducted to clarify the inconsistent findings regarding the relationship between vitamin D receptor (VDR) gene polymorphisms and the risk of developing urolithiasis (kidney stones).
- Researchers systematically reviewed 33 studies and evaluated various VDR gene single nucleotide polymorphisms (SNPs) using pooled odds ratios.
- The study concluded that while no significant overall association was found, the ApaI and TaqI SNPs were linked to a higher risk of urolithiasis in East-Asian and Caucasian populations.
Article Abstract
Background: The currently available data with respect to the association between vitamin D receptor (VDR) gene polymorphism and risk to urolithiasis are inconclusive and inconsistent. Hence, an exhaustive meta-analysis can solve the discrepancies and provide a hint for upcoming investigations. Herein, a meta-analysis was carried out to attain a conclusive estimate of the association between VDR gene single nucleotide polymorphisms (SNPs) and urolithiasis risk.
Methods: The major databases, including ISI Web of science, Scopus, and PubMed/MEDLINE were searched systematically from until June 2020 to retrieve all relevant studies. Association between VDR gene polymorphisms, including FokI (rs2228570), TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232), and urolithiasis risk was evaluated using pooled odds ratio (OR) and their corresponding 95% confidence interval (CI). Additionally, to seek for the potential source of heterogeneity, meta-regression analyses were exerted.
Results: Literature search led to finally finding of 33 studies evaluating the VDR gene SNPs and urolithiasis risk. It was observed that none of the four SNPs were significantly associated with urolithiasis predisposition. However, subgroup analysis confirmed higher risk of urolithiasis in East-Asian and Caucasian population with ApaI and TaqI gene polymorphism. The analyses of sensitivity acknowledged the results stability.
Conclusion: Although this meta-analysis did not support the association of FokI, TaqI, BsmI, and ApaI in the overall polled analysis, it suggests that ApaI and TaqI SNPs is associated with increased risk of urolithiasis in East-Asian and Caucasians populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350604 | PMC |
| http://dx.doi.org/10.1186/s12882-020-01919-1 | DOI Listing |
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