Modeling the impact of point mutations on the stability of proteins.

J Bioinform Comput Biol

Department of Molecular Biophysics, St. Petersburg State University, 199034 St. Petersburg, Russia.

Published: August 2020

A new method has been introduced which allows us to determine the stability of protein complexes with point changes of amino acid residues that also take into account the three-dimensional structure of the complex. This formulated and proven theorem is aimed at determining the criterion for the stability of protein molecules. The algorithm and software package were developed for analyzing protein interactions, taking into account their three-dimensional structure from the PDB database.

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http://dx.doi.org/10.1142/S0219720020500195DOI Listing

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