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Delayed Neurological Deficits Following Lumbar 1 Burst Fracture: A Diagnostic Challenge Without Radiological Correlates.
Cureus
December 2024
Department of Orthopedics, Spine Unit, Hospital Sungai Buloh, Sungai Buloh, MYS.
Spinal cord injuries, including rare cases without radiological abnormalities, pose diagnostic challenges, particularly in cases of delayed neurological deficit development. This case report describes a 55-year-old man with a stable L1 burst fracture who developed delayed neurological deficits two weeks after sustaining a fall despite no evidence of intrinsic or extrinsic spinal cord abnormalities on magnetic resonance imaging (MRI). The patient initially presented with back pain, normal muscle strength across all myotomes, and imaging that showed no canal stenosis or retropulsion fragments.
View Article and Find Full Text PDF3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair.
Bioact Mater
April 2025
State Key Laboratory of New Ceramics and Fine Processing, Key Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.
Biomimetic neural substitutes, constructed through the bottom-up assembly of cell-matrix modulus via 3D bioprinting, hold great promise for neural regeneration. However, achieving precise control over the fate of neural stem cells (NSCs) to ensure biological functionality remains challenging. Cell behaviors are closely linked to cellular dynamics and cell-matrix mechanotransduction within a 3D microenvironment.
View Article and Find Full Text PDFAtlantoaxial Subluxation Related to Axial Spondylarthritis: A Case-Based Systematic Review.
Mediterr J Rheumatol
December 2024
Department of Rheumatology.
Aim: Atlantoaxial dislocation is a loss of stability between the atlas and axis. It is rarely reported in patients with axial spondylarthritis. We present an axial spondylarthritis case revealed by atlantoaxial subluxation.
View Article and Find Full Text PDFComplex staged hybrid repair of extent II thoracoabdominal aortic aneurysm secondary to type A aortic dissection.
J Vasc Surg Cases Innov Tech
April 2025
Division of Vascular Surgery, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada.
Despite advancements in surgical techniques and critical care, managing complications of type A and B aortic dissections remains challenging. Common morbidities include paraplegia, renal failure, stroke, and intestinal ischemia. Risks are especially high in extensive repairs, such as Crawford extent II thoracoabdominal aortic aneurysms, and in older patients or those with heart failure, poor pulmonary function, or renal disease.
View Article and Find Full Text PDFIntrathecal transplantation of human umbilical cord mesenchymal stem cells enhances spinal cord injury recovery: Role of miR‑124‑3p as a biomarker.
Exp Ther Med
March 2025
Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830000, P.R. China.
Spinal cord injury (SCI) is a severe condition that often leads to permanent functional impairments. The current treatment options are limited and there is a need for more effective treatments. Human umbilical cord mesenchymal stem cells (hUCMSCs) have shown promise in promoting neuroregeneration and modulating immune response.
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