AI Article Synopsis
- HLH is a rare but potentially fatal condition that requires prompt diagnosis and treatment, often triggered by genetic factors, infections, malignancies, or autoimmune diseases.
- Malignancy-related HLH is often seen with T/NK-cell lymphomas but can also occur with B-cell lymphomas, demonstrating its complexity.
- A specific case is presented where a patient with HLH from Epstein Barr virus (EBV) later developed EBV-positive diffuse large B-cell lymphoma in the brain, underscoring the diagnostic challenges linked to EBV infections and HLH.
Article Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal disease if not diagnosed and treated promptly. HLH can be due to genetic factors or infections, malignancies and collagen-associated vascular diseases. Malignancy-associated HLH is not only more common in the setting of T/NK-cell lymphomas, but may also rarely be seen in the setting of B-cell lymphoma. Here, we describe a unique case of a patient who initially was diagnosed with HLH secondary to Epstein Barr virus (EBV) infection and subsequently developed EBV-positive diffuse large B-cell lymphoma affecting the brain. This case highlights the spectrum of findings associated with EBV infections and the challenges in diagnosing underlying diseases associated with HLH.
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| http://dx.doi.org/10.1093/jnen/nlaa061 | DOI Listing |
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