AI Article Synopsis
- The review focuses on two rare liver conditions found mostly in children: hepatic mesenchymal hamartoma (HMH), which is benign and typically occurs in infants, and undifferentiated embryonal sarcoma of the liver (UESL), a malignant tumor usually seen in older children.
- UESL may develop in patients with a history of HMH, and both tumors share similar chromosomal abnormalities.
- Diagnosis relies heavily on histological analysis, as their clinical and radiological signs may vary, with discussions on their characteristics, causes, and treatment options included.
Article Abstract
This review highlights two rare entities that are predominantly seen in children: hepatic mesenchymal hamartoma (HMH) and undifferentiated embryonal sarcoma of the liver (UESL). HMH is a benign lesion predominantly seen in the first 2 years of life, while UESL is malignant and usually identified in patients between 6 and 10 years of age. UESL may arise in the background of HMH, and the association has been supported by similar chromosomal aberrations (19q13.4). The diagnosis of both lesions is primarily based on histologic evaluation, as the clinical and radiological features are not always typical. The clinicopathologic characteristics, pathogenesis, differential diagnoses and treatment for both lesions are discussed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338921 | PMC |
| http://dx.doi.org/10.2217/hep-2020-0002 | DOI Listing |
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