AI Article Synopsis
- Researchers studied how different types of proton radiation (minibeams vs. broad beams) affect healthy brain tissue in juvenile mice.
- Mice received specific doses of proton radiation and were monitored for brain health over eight months, showing no significant neurologic issues.
- The minibeam technique resulted in less hair loss and reduced chronic inflammation compared to broad beams, suggesting it could better protect healthy brain tissue and is worth exploring further in clinical settings.
Article Abstract
Proton minibeams (MBs) comprised of parallel planar beamlets were evaluated for their ability to spare healthy brain compared to proton broad beams (BBs). Juvenile mice were given partial brain irradiation of 10 or 30 Gy integral dose using 100 MeV protons configured either as BBs or arrays of 0.3-mm planar MBs spaced 1.0 mm apart on center. Neurologic toxicity was evaluated during an 8-month surveillance: no overt constitutional or neurologic dysfunction was noted for any study animals. Less acute epilation was observed in MB than BB mice. Persistent chronic inflammation was noted along the entire BB path in BB mice whereas inflammation was confined to just within the MB peak regions in MB mice. The potential neurologic sparing, possibly via reduced volume of chronic inflammation, offers a compelling rationale for clinical advancement of this proton technique.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347840 | PMC |
| http://dx.doi.org/10.1038/s41598-020-68015-0 | DOI Listing |
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