Purpose: To determine the prevalence and characterise the significance of incidental findings on whole-body MRI in paediatric and adult populations.
Methods: A retrospective, single-institution study over a period of 8 years. The study population comprised 325 paediatric (0-18 yrs) patients and 148 adults (19-40 yrs) referred to a specialist musculoskeletal oncology centre, who underwent whole-body MRI for a range of pathological indications. Incidental findings were recorded according to pathology (musculoskeletal or non-musculoskeletal), site and clinical relevance.
Results: Eighty-seven of 325 (26.8 %) paediatric patients and 51 of 148 (35.8 %) adults had incidental findings detected on whole-body MRI. The most common site was the musculoskeletal system, and within this location the lower limbs. Eighty-nine percent of incidental findings in paediatric patients and 79 % of incidental findings in adults were classified as being of either minor or no clinical significance.
Conclusion: Incidental findings are common in paediatric and adult patients undergoing whole-body MRI, and are most frequently found in the lower limbs. The overwhelming majority are of minor clinical significance.
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http://dx.doi.org/10.1016/j.ejrad.2020.109156 | DOI Listing |
Eur J Epidemiol
January 2025
Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
The Stockholm Early Detection of Cancer Study (STEADY-CAN) cohort was established to investigate strategies for early cancer detection in a population-based context within Stockholm County, the capital region of Sweden. Utilising real-world data to explore cancer-related healthcare patterns and outcomes, the cohort links extensive clinical and laboratory data from both inpatient and outpatient care in the region. The dataset includes demographic information, detailed diagnostic codes, laboratory results, prescribed medications, and healthcare utilisation data.
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January 2025
Departments of Medicine and Pediatrics, Warren Alpert Medical School at Brown University, Providence, Rhode Island, USA.
Limited data exist on cancer screening in carceral facilities. This study evaluates the feasibility and outcomes of a population-based lung cancer screening initiative in a carceral setting. This is a retrospective review of a lung cancer screening event at the Rhode Island Department of Corrections.
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January 2025
Abteilung für Plastische und Handchirurgie UniversitätsCentrum für Orthopädie, Unfall- & Plastische Chirurgie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany.
Background: Kirner deformity is a rare anomaly of the little finger in adolescents, characterized by a deformity of the distal phalanx and a radiologically L-shaped epiphysis, along with palmar and radial angulation of the distal phalanx. Due to the rarity of these pathological findings, there are no systematic literature reviews available. This work serves as an overview of the clinical presentation, frequency and age distributions, as well as possible conservative and surgical treatment options.
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University of Iowa, Iowa City, IA, USA.
Background: It is increasingly apparent that tau pathology in Alzheimer's disease (AD) begins in the brainstems of middle-aged patients, decades before the onset of symptoms. Most studies are, however, based on brain-bank cohorts and focus on patients dying of natural causes. The true incidence of tau pathology in the brainstem thus remains unclear.
View Article and Find Full Text PDFAlzheimers Dement
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Anesthesia, Critical Care & Pain Medicine, Boston, MA, USA.
Background: Spouses of Alzheimer's disease (AD) patients are at a higher risk of developing incidental dementia. However, the causes and underlying mechanism of this clinical observation remain largely unknown. One possible explanation is linked to microbiota dysbiosis, a condition that has been associated with AD.
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