We developed a mitochondrion-targeting Mn-terpyridine complex (MTP) for two-photon photodynamic therapy. MTP was subjected to two-photon excitation in the NIR region to generate O and hence produce a PDT effect. This use of MTP overcame the drawbacks of traditional PDT agents. The Mn center of MTP apparently catalyzed the HO-mediated production of ROS and oxygen, which subsequently promoted the O generation, furthering the PDT effect. Additionally, the mitochondrion targeting of MTP provided a good spatial condition for the generation of O, which further promoted the PDT effect.
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