AI Article Synopsis
- Sleep-dependent synaptic plasticity is essential for effective cognitive functioning, but determining whether synapses strengthen or weaken during sleep has been difficult.
- Recent findings indicate both synaptic potentiation (strengthening) and depotentiation (weakening) occurring in this context.
- The review highlights advances in 3D electron microscopy, which has enhanced our understanding of structural synaptic changes during both sleep and wakefulness.
Article Abstract
Sleep-dependent synaptic plasticity is crucial for optimal cognition. However, establishing the direction of synaptic plasticity during sleep has been particularly challenging since data in support of both synaptic potentiation and depotentiation have been reported. This review focuses on structural synaptic plasticity across sleep and wake and summarizes recent developments in the use of 3-dimensional electron microscopy as applied to this field.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326289 | PMC |
| http://dx.doi.org/10.1016/j.cophys.2019.12.007 | DOI Listing |
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