AI Article Synopsis
- Pseudorabies virus (PRV), primarily a veterinary pathogen affecting animals like pigs, has recently been linked to human infections resulting in serious conditions like endophthalmitis and encephalitis.
- A study analyzing 1,335 serum samples from encephalitis patients found PRV positivity rates of 12.16%, 14.25%, and 6.52% in the years 2012, 2013, and 2017 respectively, indicating a trend over time.
- The higher prevalence of PRV antibodies in encephalitis patients compared to healthy individuals in 2017 suggests that some cases of human encephalitis might be attributed to PRV infections, highlighting a potential emerging health concern.
Article Abstract
Pseudorabies virus (PRV), a veterinary pathogen that infects domestic animals as well as wild animals such as wild boar and feral swine, was recently reported to infect human and led to endophthalmitis and encephalitis. A retrospective seroepidemiologic survey was conducted using 1,335 serum samples collected from patients with encephalitis and ELISA positive rates were 12.16%, 14.25%, and 6.52% in 2012, 2013, and 2017, respectively. The virus neutralizing antibody titers of positive samples correlated well with ELISA results. The pseudorabies virus antibody positive rate of patients with encephalitis were higher than that of healthy people in 2017. The above results suggest that some undefined human encephalitis cases may be caused by PRV infection.
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| http://dx.doi.org/10.3967/bes2020.059 | DOI Listing |
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