Correction to: Baseline-adjusted proportional odds models for the quantification of treatment effects in trials with ordinal sum score outcomes.

BMC Med Res Methodol

Department of Biostatistics, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, CH-8001, Zurich, Switzerland.

Published: July 2020

An amendment to this paper has been published and can be accessed via the original article.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346663PMC
http://dx.doi.org/10.1186/s12874-020-01028-5DOI Listing

Publication Analysis

Top Keywords

correction baseline-adjusted
4
baseline-adjusted proportional
4
proportional odds
4
odds models
4
models quantification
4
quantification treatment
4
treatment effects
4
effects trials
4
trials ordinal
4
ordinal sum
4

Similar Publications

Article Synopsis
  • Balcinrenone (AZD9977) is a selective mineralocorticoid receptor modulator being tested for heart failure treatment alongside dapagliflozin, particularly for patients with impaired kidney function.
  • A study involving 62 healthy male participants evaluated various oral doses of balcinrenone to assess its impact on the QT interval using electrocardiograms and plasma concentration measurements.
  • The analysis suggested that balcinrenone does not significantly prolong the QT interval, even at high therapeutic doses, remaining below the regulatory concern threshold.
View Article and Find Full Text PDF

Partitioned polygenic scores (pPS) have been developed to capture pathophysiologic processes underlying type 2 diabetes (T2D). We investigated the association of T2D pPS with diabetes-related traits and T2D incidence in the Diabetes Prevention Program. We generated five T2D pPS (β-cell, proinsulin, liver/lipid, obesity, lipodystrophy) in 2,647 participants randomized to intensive lifestyle, metformin, or placebo arms.

View Article and Find Full Text PDF

The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses.

Pharmacol Res Perspect

April 2024

Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Article Synopsis
  • Mitiperstat is being studied as a treatment for heart failure, non-alcoholic steatohepatitis, and chronic obstructive pulmonary disease, focusing on its safety regarding QT-interval prolongation.
  • In a phase 1 study, healthy male volunteers received varying doses of mitiperstat, and researchers assessed the drug's impact on QT intervals using concentration-QT modeling.
  • The findings indicated that mitiperstat does not pose a risk for QT-interval prolongation at therapeutic levels, as the predicted effect remains below regulatory concern thresholds.
View Article and Find Full Text PDF

Triangular prismatic JJ stent does not cause more discomfort than tubular ones: a randomised controlled trial comparison.

World J Urol

February 2024

Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, 1665 Kongjiang Rd. Yangpu District, Shanghai, 200092, China.

Objective: To compare the stent-related symptoms (SRS) of three commonly used, readily accessible ureteric JJ stents after uncomplicated flexible ureteroscopic lithotripsy (FURL), in a prospective randomised controlled single-blind parallel-group study, in order to see whether structural difference might influence SRS.

Patients And Methods: Patients undergoing FURL were randomised into three groups: the Cook Group received conventional 6 F Cook Universa Soft JJ stents as control, the Kang Yi Bo (KYB) Group received 6 F KYB anti-reflux JJ stents, and the Urovision Group received 7 F Urovision Visiostar ESWL JJ stents. The ureteric stent symptom questionnaire (USSQ) was administered at 1 week, 4 weeks (before stent removal), and 5 weeks (one week after stent removal as baseline evaluation) after stent insertion.

View Article and Find Full Text PDF

Background: Eyes sustaining open globe trauma are at high risk of severe visual impairment. Proliferative vitreoretinopathy is the most common cause of retinal detachment and visual loss in eyes with open globe trauma. There is evidence from experimental studies and pilot clinical trials that the use of adjunctive steroid medication triamcinolone acetonide can reduce the incidence of proliferative vitreoretinopathy and improve outcomes of surgery for open globe trauma.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!