In this work, -hexane, chloroform, and ethyl acetate fractions of the methanol extract of Houtt. seeds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) Ellman's method. It was found that all fractions depicted no anti-AChE activity, however, they were active toward BChE with IC values of 361.8, 215.0, and 145.8 µg/mL, respectively comparing with donepezil as the reference drug (IC = 1.97 µg/mL). The ethyl acetate fraction which also showed high neuroprotectivity and metal chelating ability was selected for the phytochemical analysis. Our results confirmed the presence of trimyristin and 5,7-diacetyl chrysin (reported for the first time in ) in the corresponding fraction.
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