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Evaluation of Alpha-Amylase Inhibitory, Antioxidant, and Antimicrobial Potential and Phytochemical Contents of L. | LitMetric

AI Article Synopsis

  • The study investigates the medicinal plant L. for its α-amylase inhibitory, antioxidant, and antimicrobial properties using various solvent extracts from its leaves and stem.
  • Results show that the stem contains higher levels of bioactive compounds and exhibits greater antimicrobial activity against both Gram-positive and Gram-negative bacteria compared to the leaves.
  • The stem extracts also demonstrate strong antioxidant potential, suggesting that L. could be a valuable resource for antidiabetic, antimicrobial, and antioxidant applications in industries such as food, pharmaceuticals, and cosmetics.

Article Abstract

L. is a traditionally used medicinal plant. The present study was designed to explore the α-amylase inhibitory, antioxidant, and antimicrobial activities of L. Polarity-based solvent extracts (-hexane, acetone, chloroform, methanol, ethanol, and water) of leaves and stem were used. Antioxidant activity was assessed by free radical scavenging assay (FRAP) and 2,2-diphenylpicrylhydrazyl (DPPH) free radical scavenging activity methods. Quantitative phytochemical analyses suggested that the stem of L. contains higher levels of bioactive compounds than its leaves ( < 0.05). The results suggested that stem-derived extracts of L. are more active against bacterial species, including two Gram-positive and three Gram-negative strains. Moreover, our results showed that the bioactive compounds of L. significantly inhibit α-amylase activity. Finally, we reported the polarity-based solvent extracts of L. and revealed that the stem, rather than leaves, has a high antioxidant potential as measured by FRAP and DPPH assay with IC values of 1.38 and 1.59 mg/mL, respectively. It may also be deducted from the data that the L. could be a significant candidate, which should be subjected to further isolation and characterization, to be used as an antidiabetic, antimicrobial and antioxidant resource in many industries, like food, pharmaceuticals and cosmetics.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412011PMC
http://dx.doi.org/10.3390/plants9070852DOI Listing

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