In this issue of Structure, Urbanek et al. (2020a) combine site-specific isotope labeling and NMR spectroscopy to investigate opposing effects of flanking regions onto the conformation of the poly-Q region in Huntingtin. Poly-Q interactions with preceding residues promote an α-helical conformation while a following proline-rich region favors extended conformations.
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| http://dx.doi.org/10.1016/j.str.2020.06.005 | DOI Listing |
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