Finding the Sweet Spot: Parsing Tissue-Specific Contributions of Fructose Metabolism.

Cell Metab

Internal Medicine Research Unit, Pfizer Worldwide Research, Discovery and Medical, Cambridge, MA, USA. Electronic address:

Published: July 2020

The abundance of dietary sweeteners and overconsumption of fructose are widely thought to promote metabolic disease. In this issue of Cell Metabolism, Andres-Hernando et al. (2020) identify the liver as the major site of fructose metabolism-mediated metabolic dysfunction and identify a surprising role for intestinal fructose metabolism in driving fructose intake.

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http://dx.doi.org/10.1016/j.cmet.2020.06.009DOI Listing

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