Salivary gland hyalinizing clear-cell carcinoma with cutaneous metastasis: A rare and deceptive tumor.

J Cutan Pathol

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan, USA.

Published: January 2021

Clear-cell carcinoma (CCC) is an uncommon malignant tumor of minor salivary glands. It characteristically has a low-grade morphology and a favorable outcome by most reports. An EWSR1-ATF1 fusion can be detected in the majority of cases. We present a rare case of CCC, which had an aggressive course with the development of cutaneous metastases. Practicing dermatopathologists should be aware of this tumor given its low-grade appearance and histopathologic resemblance to other primary cutaneous adnexal and metastatic neoplasms.

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http://dx.doi.org/10.1111/cup.13799DOI Listing

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