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Out of Sight, Out of Mind? Neuronal Gamma Oscillations During Occlusion Events in Infants.
Dev Psychobiol
January 2025
Developmental Neuroscience Laboratory, Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Object permanence allows infants to interact successfully with objects in the environment. What happens in the human infant brain when objects move in and out of sight? This study used high-density electroencephalography (hdEEG) to record induced oscillatory brain activities in 29 locomotor infants before, during, and after occlusion of a moving object traveling at different speeds. Temporal spectral evolution (TSE) showed that before and after the occlusion event, event-related synchronized (ERS) brain activity was observed, whereas event-related desynchronized (ERD) activity was detected when the car was hidden behind the occluder.
View Article and Find Full Text PDFPROTAC delivery in tumor immunotherapy: Where are we and where are we going?
J Control Release
December 2024
Key Laboratory of Smart Drug DeliveryMinistry of Education, Minhang Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China; Department of Digestive Diseases, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China. Electronic address:
Immunotherapy has emerged as a pioneering therapeutic modality, particularly within the realm of oncology, where Chimeric Antigen Receptor T-cell (CAR-T) therapy has manifested significant efficacy in the treatment of hematological malignancies. Nonetheless, the extension of immunotherapy to solid tumors poses a considerable challenge. This challenge is largely attributed to the intrinsic "cold" characteristics of certain tumors, which are defined by scant T-cell infiltration and a diminished immune response.
View Article and Find Full Text PDFPrevalence and psycho-social factors associated with alcohol use among primary school-going children aged 6 to 13 years in Mbale district, Uganda: a cross-sectional study.
BMC Pediatr
November 2024
Department of Pediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Article Synopsis
- * A total of 470 child-parent pairs were surveyed using the CRAFFT screening tool, revealing 7.2% had Alcohol Use Disorder (AUD), with similar prevalence in boys and girls.
- * Key factors associated with alcohol use included being from single-parent households, lower caregiver education, low socioeconomic status, food insecurity, and peer influence.
Role of Immunotherapy in Conjunction With the Surgical Treatment of Breast Cancer: Preoperative and Postoperative Applications.
Cureus
October 2024
School of Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Muharraq, BHR.
Breast cancer is one of the most common cancers in the world. Since the appearance of molecular medicine, the perspective of breast cancer treatment has changed, making it more successful in comparison with the treatment during previous years. Numerous ongoing trials are exploring the capacity of immunotherapy, mainly in immune checkpoint inhibitors (ICIs), in conjunction with conventional therapies or with antibody-drug conjugates (ADCs).
View Article and Find Full Text PDFassessment of CAR macrophages activity against SARS-CoV-2 infection.
Heliyon
November 2024
Department of Civil, Energy, Environment and Materials Engineering, Università'Mediterranea' di Reggio Calabria, Via R. Zehender 1, Feo di Vito, I-89122, Reggio Calabria, Italy.
Macrophage engineering with chimeric antigen receptor is a promising technique first applied to the treatment of tumours and recently suggested as a possible immunotherapeutic route against the COVID-19 disease. Four immunotherapies based on engineered macrophages have been tested revealing promising, with one of them acting without increasing the cytokines level. We present a mathematical model aimed at the evaluation of both the SARS-CoV-2 virions dynamics and the cytokines production induced, while such newly developed constructs interact with the immune system once administered.
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