Antifungal Phenols from Collected in Oman.

is a flowering shrub unique to the Dhofar region of Oman and is used locally as a sedative and remedy for skin infection. However, no study to date has examined the pharmacological properties of this plant, and studies regarding phytochemicals present in are limited. Herein, phytochemical screening of the extract of was performed using LC/MS. Three new phenolic compounds, (±)-woodfordiamycin (), woodfordic acid (), and rhamnetin 3--(6″-galloyl)-β-d-glucopyranoside (), together with 16 known compounds -, were isolated from the antifungal fraction of the extract. The structures of the new compounds were established by NMR and HR-MS data, and their absolute configurations were established using chemical transformations, including Mosher's method, comparison of experimental and calculated electronic circular dichroism data, and gauge-including atomic orbital NMR chemical shift calculations, followed by DP4+ analysis. The isolated compounds (-) were tested for antifungal activity against human fungal pathogens and . Compounds (±) and showed antifungal activity against , with the lowest minimum inhibitory concentrations of 1.8-1.9 μM, which was ∼10-fold lower than that of the currently available antifungal drug fluconazole, while (±), , and showed antifungal activity against .