AI Article Synopsis
- FPR2 is a G protein-coupled receptor primarily found in immune cells, playing a crucial role in fighting bacterial infections and clearing damaged cells through neutrophil activity.
- FPR2 may also influence inflammation in conditions like osteoarthritis.
- The study demonstrates that both healthy and osteoarthritic human articular chondrocytes express FPR2 at mRNA and protein levels, but the exact significance of this expression requires further research.
Article Abstract
The formyl peptide receptor 2 (FPR2) belongs to the family of seven-transmembrane G protein-coupled receptors (GPCR) and are expressed by many different cells but mainly studied in immune cells. FPR2 is involved in host defense against bacterial infections and clearance of damaged cells through the oxidative burst and chemotaxis of neutrophils. In addition, FPR2 has also been implicated as an immunomodulator in sterile inflammations, e.g. inflammatory joint diseases. Here we present data regarding FPR2 expression in human articular chondrocytes, isolated from healthy individuals and osteoarthritic patients, on both mRNA and protein level using qPCR and Imagestream flow cytometry. We also present data after receptor stimulation and monitoring of production of nitric oxide, reactive oxygen species, IL-6, IL-8 and MMP-3. The presented data show that human articular chondrocytes from patients with osteoarthritis as well as from healthy individuals express FPR2 both at mRNA and protein level. The biological relevance of FPR2 expression in chondrocytes needs to be further investigated.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326719 | PMC |
| http://dx.doi.org/10.1016/j.dib.2020.105866 | DOI Listing |
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