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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324582 | PMC |
| http://dx.doi.org/10.1038/s41421-020-0178-7 | DOI Listing |
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As one of the most abundant DNA methylation form in prokaryotes, N-methyladenine nucleotide (6 mA) was however only recently identified in eukaryotic genomes. To explore the implications of N-adenine methylation in adipogenesis, genomic N-adenine methylation was examined across adipocyte differentiation stages of 3T3-L1 cells. When the N-adenine methylation profiles were analyzed and compared with the levels of gene expression, a positive correlation between the density of promoter 6 mA and gene expression level was uncovered.
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