Background: Specific genomic profile of cutaneous melanomas is related to UVR exposure, which exerts biological and therapeutic impact. Subungual melanoma (SUM) is an exceedingly rare disease; therefore, it is not well characterized. SUM pathogenesis is not related to UVR induced DNA damage and expected to differ from other melanoma subtypes. Our study aimed to define the mutation profile of SUM in Caucasians.

Materials And Methods: Next-generation sequencing-based genomic analysis was used to identify frequently mutated loci in 50 cancer-related genes in 31 SUM primary tumors.

Results: The most abundant mutations in SUM were found in - in 13% of cases and - also in 13%, while - only in 3% of cases.

Conclusions: Our findings confirmed a high frequency of and mutations in SUM, as well as a low incidence of mutations. We reported novel , , , , and mutations in SUM. Our findings provide new insights into the molecular pathogenesis of SUM.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321700PMC
http://dx.doi.org/10.18632/oncotarget.27642DOI Listing

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