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http://dx.doi.org/10.1161/CIRCRESAHA.120.317025 | DOI Listing |
Circ Res
August 2020
From the UCL Institute of Ophthalmology, University College London, United Kingdom (J.T.B., R.L.B., V.S.R., L.D., C.R.).
Proc Natl Acad Sci U S A
February 2016
Department of Pathology, University of California San Diego, La Jolla, CA 92093;
LDL receptor-related protein-1 (LRP1) is an endocytic and cell-signaling receptor. In mice in which LRP1 is deleted in myeloid cells, the response to lipopolysaccharide (LPS) was greatly exacerbated. LRP1 deletion in macrophages in vitro, under the control of tamoxifen-activated Cre-ER(T) fusion protein, robustly increased expression of proinflammatory cytokines and chemokines.
View Article and Find Full Text PDFOsteoarthritis Cartilage
July 2015
Genomics and Immunology Laboratory, St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, Fitzroy, VIC 3065, Australia. Electronic address:
Objective: In growth plate chondrocytes, loss of Dicer, a microRNA (miRNA)-processing enzyme, causes defects in proliferation and differentiation, leading to a lethal skeletal dysplasia. However roles of miRNAs in articular chondrocytes have not been defined in vivo. To investigate the role of miRNAs in articular chondrocytes and to explore the possibility of generating a novel mouse osteoarthritis (OA) model caused by intrinsic cellular dysfunction, we ablated Drosha, another essential enzyme for miRNA biogenesis, exclusively in articular chondrocytes of postnatal mice.
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