AI Article Synopsis
- Vitamin D is converted in the body into two active forms that help boost the immune response, particularly in immune cells.
- Mice given a high dose of 25-hydroxyvitamin D showed lower viral levels after being infected with the influenza A virus compared to those on a regular diet.
- The study found that the high-dose 25(OH)D reduced inflammatory cytokines while not significantly increasing anti-inflammatory cytokines, suggesting it may help control influenza infections.
Article Abstract
Vitamin D is a fat-soluble vitamin that is metabolized by the liver into 25-hydroxyvitamin D [25(OH)D] and then by the kidney into 1,25-dihydroxyvitamin D [1,25(OH)D], which activates the vitamin D receptor expressed in various cells, including immune cells, for an overall immunostimulatory effect. Here, to investigate whether oral supplementation of 25-hydroxyvitamin D [25(OH)D], a major form of vitamin D metabolite 25(OH)D, has a prophylactic effect on influenza A virus infection, mice were fed a diet containing a high dose of 25(OH)D and were challenged with the influenza virus. In the lungs of 25(OH)D-fed mice, the viral titers were significantly lower than in the lungs of standardly fed mice. Additionally, the proinflammatory cytokines IL-5 and IFN-γ were significantly downregulated after viral infection in 25(OH)D-fed mice, while anti-inflammatory cytokines were not significantly upregulated. These results indicate that 25(OH)D suppresses the production of inflammatory cytokines and reduces virus replication and clinical manifestations of influenza virus infection in a mouse model.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400405 | PMC |
| http://dx.doi.org/10.3390/nu12072000 | DOI Listing |
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