Organelle Biogenesis: ER Shape Influences Lipid Droplet Nucleation.

Curr Biol

Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94720, USA. Electronic address:

Published: July 2020

Lipid droplets (LDs) are neutral lipid storage organelles assembled at the endoplasmic reticulum (ER). A new study reveals that the high membrane curvature of ER tubules catalyzes the nucleation of a neutral lipid lens, an early step in LD biogenesis.

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http://dx.doi.org/10.1016/j.cub.2020.05.027DOI Listing

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