Purpose: To assess the role of spatial frequency on binocular imbalance in binocular combination in adults with amblyopia.
Methods: Ten amblyopes (23 ± 4.9 [SD] years old; one deprivation, two mixed, seven anisometropia patients) and 10 age-matched normal adults (23 ± 2.3 years old) participated. The interocular contrast ratio (fellow eye/amblyopic eye, i.e., the balance point [BP]) that resulted in an equal contribution of both eyes in binocular combination was measured using a binocular orientation combination task at 0.5, 1, 2, and 4 cycles per degree (c/d). The extent of binocular imbalance was quantified as the absolute value of the BP on log scale (i.e., |logBP|).
Results: When the base contrast of the amblyopic eye was set at 100% (Experiment 1), the |logBP| was found to be significantly affected by stimulus spatial frequency (F(1.44, 26.01) = 51.6, P < 0.001, \({\rm{\eta }}_g^2\)= 0.40) and group (F(1, 18) = 66.97, P < 0.001, \({\rm{\eta }}_g^2\) = 0.74), the interaction between spatial frequency and group was also significant (F(1.44, 26.01) = 38.12, P < 0.001, \({\rm{\eta }}_g^2\)= 0.33). Such spatial frequency-dependent binocular imbalance remained present, even when the base contrast of the amblyopic eye was set at equal suprathreshold contrast levels across spatial frequencies (Experiment 2).
Conclusions: Binocular balance was more disrupted at higher spatial frequencies in binocular combination in amblyopia. This imbalance might not originate solely from the amblyopic eye's deficit in contrast sensitivity but is likely to be related to the difference in contrast sensitivity between the eyes.
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http://dx.doi.org/10.1167/iovs.61.8.7 | DOI Listing |
Int J Ophthalmol
January 2025
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Aim: To evaluate the effect of femtosecond laser small incision lenticule extraction (SMILE) on the binocular visual function in myopic patients with glasses-free three-dimensional (3D) technique.
Methods: Totally 50 myopic patients (39 females and 11 males) with SMILE were enrolled in this prospective study. The glasses-free 3D technique was used to evaluate the binocular visual function in these subjects including static stereopsis, dynamic stereopsis, foveal suppression, and binocular balance point of signal to noise ratio (s/n ratio).
J Vis
January 2025
McGill Vision Research, Department of Ophthalmology & Visual Sciences, McGill University, Montreal, QC, Canada.
Here, we investigate the shift in eye balance in response to monocular cueing in adults with amblyopia. In normally sighted adults, biasing attention toward one eye, by presenting a monocular visual stimulus to it, can shift eye balance toward the stimulated eye, as measured by binocular rivalry. We investigated whether we can modulate eye balance by directing monocular stimulation/attention in adults with clinical binocular deficits associated with amblyopia and larger eye imbalances.
View Article and Find Full Text PDFSci Rep
January 2025
Department Ophthalmology and Visual Sciences, McGill Vision Research, McGill University, Montreal, QC, Canada.
In amblyopia, abnormal binocular interactions lead to an overwhelming dominance of one eye. One mechanism implied in this imbalance is the suppression between the inputs from the two eyes. This interocular suppression involves two components: an overlay suppression and a surround suppression.
View Article and Find Full Text PDFHeliyon
October 2024
Guangdong Provincial Key Laboratory of Brain Function and Disease, Center for Brain and Mental Wellbeing, Department of Psychology, Sun Yat-sen University, Guangzhou, Guangdong, China.
Purpose: The current study aims to implement steady-state visual evoked potentials (SSVEPs) in quantifying the binocular imbalance of amblyopia and to assess the predictive value of SSVEP-derived indices for amblyopic stereoacuity.
Methods: We measure frequency-tagged SSVEP responses elicited by each eye (F1 = 6 Hz through the fellow eye; F2 = 7.5 Hz through the amblyopic eye) within a binocular rivalry paradigm among a cohort of anisometropic amblyopic observers (n = 29, mean age: 12 years).
J Vis
October 2024
McGill Vision Research, Department of Ophthalmology and Visual Sciences, McGill University; McGill University Health Center, Montreal, QC, Canada.
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