AI Article Synopsis
- Large genomic deletions (LGDs) ranging from 6 to 63 kbp were found in isoniazid-resistant mutants from four different strains.
- The LGDs didn't affect overall growth but may impair intracellular growth and show varied responses to oxidative stress.
- The deleted regions included 74 genes, mostly unknown, which could play a role in intracellular growth and defense against oxidative stress.
Article Abstract
Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant mutants derived from four strains. These LGDs had no growth defect but could be defective in intracellular growth and showed various sensitivities toward oxidative stress despite lacking The LGD regions comprise 74 genes, mostly of unknown function, that may be important for intracellular growth and protection against oxidative stress.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449219 | PMC |
| http://dx.doi.org/10.1128/AAC.00792-20 | DOI Listing |
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