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Late corneal guttae recurrence in bilateral penetrating keratoplasty grafts.
Eur J Ophthalmol
January 2025
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Background: To describe a case of guttae recurrence in bilateral corneal grafts in a patient with a known diagnosis of Fuchs endothelial dystrophy, more than three decades following penetrating keratoplasty.
Methods: Case Report.
Results: A 79-year-old White woman presented with declining vision, right eye worse than the left.
Background: Frequently utilized Alzheimer's disease (AD) preclinical models rely on risk factors expressed in familial AD, which accounts for <1% of the clinical AD population. Apolipoprotein (APOE) ε4 is the strongest genetic risk factor for the development of the more prevalent late-onset Alzheimer's disease (LOAD). MRI studies demonstrate a link between APOE-ε4 and reduced gray matter volume as well as lower fractional anisotropy (FA) in AD patients.
View Article and Find Full Text PDFBackground: Hemodynamic signals are the basis of functional brain imaging techniques, such as fMRI and NIRS, and are often used to infer changes in resting-state functional connectivity (RSFC) in Alzheimer's disease (AD) and other dementias. Increasing evidence suggests that disruption of neuronal circuits has been associated with the AD continuum and may precede changes in Ab and tau biomarkers, neurodegeneration, and cognitive impairment. To better understand the changes in brain RSFC through the AD spectrum, we use hemodynamic signals to detect disease onset, progression, and response to therapy in a mouse model of AD.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina Del Rey, CA, USA.
Background: Carrying one or more copies of the apolipoprotein E ε4 allele represents the greatest known source of genetic risk for late-onset Alzheimer's disease (AD), although the mechanisms are not fully understood. Several smaller-scale studies have analyzed APOEε4 effects on brain volume, reporting gray matter volume (GMV) alterations in medial temporal and precuneal regions in people with AD and in healthy APOEε4 carriers. Here, we analyzed brain images from a large sample of healthy elderly adults in relation to ε4 carrier status, stratifying by age to assess potential group differences.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Frontotemporal Disorders Unit and Massachusetts Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Background: APOE-ɛ4 is a major risk factor for Alzheimer's disease (AD); its effects have been examined in late-onset AD (LOAD) but less so in early-onset AD (EOAD). In LOAD, APOE genotype has strong effects on episodic memory and medial temporal lobe (MTL) atrophy (Wolk & Dickerson, 2010). However, EOAD often presents with more cognitive impairments in executive function, language, and visuospatial abilities than memory.
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