AI Article Synopsis
- Three new flavonoids and two new alkaloids were discovered from the leaves of a specific plant, along with 45 known compounds.
- One notable compound, 1-octacosanol, showed potential as a natural laxative by alleviating constipation in mice for the first time.
- The researchers used gas chromatography-tandem mass spectrometry (GC-MS/MS) for precise quantification of the compound and also evaluated the anti-inflammatory and α-glucosidase inhibitory activities of some other compounds.
Article Abstract
Three new flavonoids, quercetin-3--6-[methyl-()-3-hydroxy-3-methylglutaroyl(1→6]-β-d-glucopyranoside (), kaempferol-3--[methyl-()-3-hydroxy-3-methylglutaroyl(1→6)]-β-d-glucopyranoside (), and quercetin-3--6-[()-4-methoxy-5-methylhexa-2,4-dienoatyl(1→6)]-β-d-glucopyranoside (), and two new alkaloids, 5-dehydroxymethyl-pyrrolemarumine 4″--α-l-rhamnopyranoside () and -methyl--((4--α-l-rhamnopyranoside)benzyl) oxalamide (), together with 45 known compounds (-) were isolated from the leaves of Lam. Among those compounds, 1-octacosanol (), a straight-chain 28-carbon alcohol, exhibited good activity against diphenoxylate-induced constipation in mice, which is obtained as a laxative constituent from the plant for the first time. In order to have an accurate understanding of the content of compound , a quantification with gas chromatography-tandem mass spectrometry (GC-MS/MS) was carried out. The anti-inflammatory and α-glucosidase inhibitory activity of some compounds also was assessed.
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| http://dx.doi.org/10.1021/acs.jafc.0c01564 | DOI Listing |
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