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Investigation of the protective effect of cilostazol on acute lung injury-mediated inflammation and in silico molecular modelling studies of inflammatory signalling pathway: a repurposing study.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Dr. Babasaheb Ambedkar Technological University, Lonere, Raigad, 402103, India.
Acute lung injury i.e. ALI and its serious form acute respiratory distress syndrome (ARDS) are incurable medical conditions associated with significant global mortality and morbidity.
View Article and Find Full Text PDFNetwork pharmacology and molecular docking to explore mechanisms of clozapine-induced cardiac arrest.
J Psychiatry Neurosci
January 2025
From the Computational Biology Centre and the Laboratory of Psychiatric-Neuroimaging-Genetic and Comorbidity, Tianjin Anding Hospital, Tianjin Mental Health Centre of Tianjin Medical University, Nankai University Affiliated Tianjin Anding Hospital, Tianjin, China.
Background: Clozapine is superior to all other antipsychotics in treating schizophrenia in terms of its curative efficacy; however, this drug is prescribed only as a last resort in the treatment of schizophrenia, given its potential to induce cardiac arrest. The mechanism of clozapine-induced cardiac arrest remains unclear, so we aimed to elucidate the potential mechanisms of clozapine-induced cardiac arrest using network pharmacology and molecular docking.
Methods: We identified and analyzed the overlap between potential cardiac arrest-related target genes and clozapine target genes.
Target-assisted self-powered photoelectrochemical sensor based on AgS/BiOCl heterojunction for ultrasensitive chlorpyrifos detection.
Talanta
December 2024
College of Geography and Environmental Sciences, College of Chemistry and Materials Sciences, Key Laboratory of Watershed Earth Surface Processes and Ecological Security, Zhejiang Normal University, Jinhua, 321004, China. Electronic address:
Chlorpyrifos (CPF), a widely used organophosphorus pesticide, presents substantial risks to both environmental and human health due to its persistent accumulation, thereby necessitating the development of effective detection methods. Self-powered photoelectrochemical (PEC) sensors, as an innovative technology, address the limitations inherent in conventional sensors, such as susceptibility to interference and inadequate signal response. Herein, we synthesized AgS/BiOCl as a photosensitive material, employing it as a light-harvesting substrate and a signal-transducing platform to develop a self-powered PEC sensor for the detection of CPF.
View Article and Find Full Text PDFLTBP2 silence suppresses glioblastoma proliferation and tumor growth of xenograft tumor mice through modulating JAK2/STAT2 signaling pathway.
Tissue Cell
December 2024
Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China. Electronic address:
Glioblastoma is considered the most malignant central nervous system tumor. This study aimed to investigate effects of latent transforming growth factor-β binding protein-2 (LTBP2) on glioblastoma growth and associated mechanisms. LTBP2 gene transcription in glioblastoma was determined using RT-PCR.
View Article and Find Full Text PDFTRAMP assembly alters the conformation and RNA binding of Mtr4 and Trf4-Air2.
Proc Natl Acad Sci U S A
January 2025
Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080.
Article Synopsis
- The TRAMP complex is crucial for RNA processing and features two key enzymatic activities that involve both polyadenylation and unwinding of RNA.
- New research using hydrogen-deuterium exchange data reveals insights into how TRAMP assembles and shuffles RNA between its catalytic sites, which are not fully understood.
- Findings indicate that peripheral RNA-recognition motifs affect TRAMP assembly and that different active-site subunits interact with tRNA in ways that influence RNA transfer between TRAMP components.
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