AI Article Synopsis
- The study investigates the analgesic effects of polydeoxyribonucleotide (PDRN) on neuropathic pain models, specifically spinal nerve ligation (SNL) and chronic post-ischemic pain (CPIP).
- PDRN was administered in varying doses (3.3, 10, and 20 mg/kg) to test its impact on reducing mechanical allodynia, with results showing significant pain relief, particularly at the highest dose.
- The findings suggest that PDRN not only alleviates neuropathic pain but also influences astrocyte activation, indicating its potential as a therapeutic option for managing such pain conditions.
Article Abstract
Background: Spinal nerve ligation (SNL) model is one of the representative models of the neuropathic pain model. Neuropathic pain in a chronic post-ischemic pain (CPIP) mimics the symptoms of complex regional pain syndrome (CRPS). The administration of polydeoxyribonucleotide (PDRN), which has regenerative and anti-inflammatory effects, has been studied and is used in clinical practice treating various diseases. However, the analgesic effect of PDRN in a neuropathic pain or CRPS model remains unknown.
Methods: PDRN (3.3, 10, and 20 mg/kg) was administered into the subcutaneous (SC) layer of the hind paws of SNL and CPIP models. Mechanical anti-allodynic effects were then investigated using the von Frey test. In the immunohistochemical examination, dorsal root ganglia (DRG) and the spinal cord were harvested and examined for the expression of glial fibrillary acidic protein (GFAP) after the 20 mg PDRN injection.
Results: Mechanical allodynia was significantly alleviated by administration of PDRN in SNL and CPIP mice at all of the time point. As the dose of PDRN increased, the effect was greater. The 20 mg PDRN injection was found to have the most effective anti-allodynic effect. The increased expression of GFAP in DRG and the spinal cord of SNL and CPIP model decreased following the administration of PDRN than vehicle.
Conclusion: SC administration of PDRN results in the attenuation of allodynia and activation of astrocytes in neuropathic pain or CRPS models. We propose that PDRN can have significant potential advantages in neuropathic pain treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338212 | PMC |
| http://dx.doi.org/10.3346/jkms.2020.35.e225 | DOI Listing |
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