AI Article Synopsis
- Acute myocardial infarction (AMI) is a major global health issue, highlighting the need for better detection methods beyond expensive and invasive blood tests.
- The study introduces a new nanobiosensor that combines gold nanoparticles and quantum dots to quickly and sensitively detect cardiac troponin I (cTnI) in saliva, a key biomarker for AMI.
- This innovative sensor shows a detection range of 0.4-2500 fM and a limit of detection as low as 0.3 fM, offering promising advancements in non-invasive diagnostic tools for heart conditions.
Article Abstract
Acute myocardial infarction (AMI) is one of the leading causes of death throughout the world. Usual methods for detecting AMI are expensive, time-consuming and using blood samples as biological samples. Therefore, creating an ultra-fast, sensitive and non-invasive diagnostic test is necessary. Herein, a novel ultra-sensitive, fluorescent, plasmon-exciton coupling hybrid of a gold nanoparticle-quantum dot (PQ)-based aptamer nanobiosensor is presented for the detection of human cardiac troponin I (cTnI), the golden biomarker of AMI, and a preclinical test is performed within saliva. The binding of the cTnI protein to aptamer leads to a fluorescence enhancement of the plexcitonic hybrid system. The response range of this nanobiosensor is 0.4-2500 fM and the limit of detection is 0.3 fM. It seems that this novel design of nanobiosensor in the form of the PQ plexcitonic hybrid system can presents new opportunities for nanobiosensor progress.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999242 | PMC |
| http://dx.doi.org/10.1002/elsc.201500188 | DOI Listing |
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