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| http://dx.doi.org/10.20524/aog.2020.0471 | DOI Listing |
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Incidence of hepatobiliary malignancies in primary sclerosing cholangitis: systematic review and meta-analysis.
Clin Gastroenterol Hepatol
December 2024
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
Background And Aims: Primary sclerosing cholangitis (PSC) is a known risk factor for hepatobiliary malignancies. We conducted a systematic review and meta-analysis of published studies to determine the incidence and risk factors for hepatobiliary malignancies in people with PSC.
Methods: Pubmed and Embase databases were searched from inception to April 10, 2024 for cohort studies reporting data on the incidence of cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), or gallbladder cancer (GBC) in PSC.
Primary Biliary Cholangitis: personalizing second-line therapies.
Hepatology
November 2024
Department of Medicine, Division of Gastroenterology and Hepatology, University of California Davis School of Medicine, Sacramento, California, USA.
Article Synopsis
- Primary biliary cholangitis (PBC) is an autoimmune disease primarily affecting middle-aged women, characterized by damage to small bile ducts, leading to liver issues like cholestasis and cirrhosis.
- The main treatment for PBC has been ursodeoxycholic acid, which helps slow disease progression but doesn't alleviate symptoms; new second-line therapies are being developed for patients who don't respond well.
- Recent medications like obeticholic acid, elafibranor, and seladelpar show promise in improving liver function and reducing cholestasis, while considerations for personalized treatment based on patient features are essential.
Intestinal histopathology in pediatric PSC-IBD: Characterization of phenotype and assessment of the Nancy Index.
J Pediatr Gastroenterol Nutr
December 2024
Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Background: We aimed to characterize the histologic gut phenotype of pediatric primary sclerosing cholangitis (PSC)-associated inflammatory bowel disease (IBD) against non-PSC colitis, and to assess Nancy Index (NI) performance in pediatric PSC-IBD.
Methods: Single-center retrospective cohort study including children diagnosed with PSC-IBD or non-PSC colitis (ulcerative colitis [UC] or IBD-unclassified) from 2000 to 2018, with diagnostic intestinal biopsies. Biopsies were re-reviewed by two independent pathologists who assessed microscopic disease distribution, NI scores, and specific histological features in the right and left colons, overall and stratified by endoscopic severity (moderate-severe vs.
Large balloon sphincteroplasty for CBD stone removal during acute cholangitis. Single center propensity-score matched cohort study.
Surg Endosc
December 2024
Department of Medicine, Yan Chai Hospital, Tsuen Wan, China.
Background: Endoscopic biliary drainage is the mainstay of treatment for acute cholangitis. CBD stone removal can be performed in same session with biliary drainage. Our team incorporated the use of endoscopic large balloon sphincteroplasty as an alternative for conventional papillotomy for biliary access.
View Article and Find Full Text PDFLiver Failure in Autoimmune Hepatitis Overlap Syndrome With Primary Biliary Cholangitis: A Case Report.
Cureus
November 2024
Internal Medicine, Hospital Senhora da Oliveira, Guimarães, PRT.
Article Synopsis
- * AIH frequently occurs alongside other autoimmune diseases, complicating diagnosis and treatment due to the lack of standardized protocols and the rarity of the condition, which limits research and treatment options.
- * A case study highlights a 54-year-old woman with acute hepatitis that escalated to liver failure; upon diagnosis of AIH and primary biliary cholangitis (PBC), she was treated with corticosteroids, demonstrating the complexities of overlap syndromes.
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