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Etiologies of Melanoma Development and Prevention Measures: A Review of the Current Evidence.
Cancers (Basel)
September 2021
Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY 10032, USA.
(1) Melanoma is the most aggressive dermatologic malignancy, with an estimated 106,110 new cases to be diagnosed in 2021. The annual incidence rates continue to climb, which underscores the critical importance of improving the methods to prevent this disease. The interventions to assist with melanoma prevention vary and typically include measures such as UV avoidance and the use of protective clothing, sunscreen, and other chemopreventive agents.
View Article and Find Full Text PDFHeritability of tanning addiction: A twin concordance study.
J Am Acad Dermatol
November 2020
Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio; Johns Hopkins School of Medicine, Department of Dermatology, Baltimore, Maryland.
Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort.
J Med Genet
November 2018
GenomesForLife-GCAT Lab Group, Program of Predictive and Personalized Medicine of Cancer (PMPPC), Germans Trias i Pujol Research Institute (IGTP), Crta. de Can Ruti, Badalona, Catalunya, Spain.
Background: Heritability estimates have revealed an important contribution of SNP variants for most common traits; however, SNP analysis by single-trait genome-wide association studies (GWAS) has failed to uncover their impact. In this study, we applied a multitrait GWAS approach to discover additional factor of the missing heritability of human anthropometric variation.
Methods: We analysed 205 traits, including diseases identified at baseline in the GCAT cohort (Genomes For Life- Cohort study of the Genomes of Catalonia) (n=4988), a Mediterranean adult population-based cohort study from the south of Europe.
Intrinsic and extrinsic risk factors for sagging eyelids.
JAMA Dermatol
August 2014
Department of Dermatology, Erasmus Medical Center, Rotterdam, the Netherlands.
Importance: Sagging eyelids, or dermatochalasis, are a frequent concern in older adults. It is considered a feature of skin aging, but risk factors other than aging are largely unknown.
Objective: To study nongenetic and genetic risk factors for sagging eyelids.
Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.
Int J Cancer
August 2009
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Human pigmentation is a polygenic quantitative trait with high heritability. Although a large number of single nucleotide polymorphisms (SNPs) have been identified in pigmentation genes, very few SNPs have been examined in relation to human pigmentary phenotypes and skin cancer risk. We evaluated the associations between 15 SNPs in 8 candidate pigmentation genes (TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP and ATRN) and both pigmentary phenotypes (hair color, skin color and tanning ability) and skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases and 870 common controls.
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