Background And Aim: Metabolic syndrome is rising at an alarming rate in developing countries. In India, increasing influence of urbanization in the rural areas is responsible for transition in lifestyle and diet of the indigenous people. Therefore, this study aims to estimate the prevalence of metabolic syndrome and the associated risk factors among the adolescents of Kukana tribe of Valsad district, Gujarat.
Methods: A cross-sectional study was conducted on 296 adolescents (128 boys and 168 girls) aged 14-19 years. Semi-structure interview schedule including demographic characteristics like age, sex, clan, native village was administered. Anthropometric measurements (height, body weight, waist circumference), systolic and diastolic blood pressure, biochemical tests were recorded. Data was entered in MS-Excel, and SPSS was used to analyse descriptive statistics (mean and standard deviations), frequencies and test of significance such t-test and chi-square. Prevalence of metabolic syndrome and associated risk factors was determined by National Cholesterol Education Program Adult Treatment Panel III modified for adolescents by Cook's criteria.
Results: Overall prevalence of metabolic syndrome was estimated as 3.8%, with sex-wise prevalence found to be 3.9% and 3.6% in boys and girls, respectively. Low High-Density Lipoprotein Cholesterol was the most prevalent individual risk factor observed in the present study.
Conclusion: This study is the first study which assessed metabolic syndrome and its components in tribal adolescents in India. Tribal communities are susceptible a triple burden of diseases. Micro-level and grassroot community-based studies should be designed and carried out in tribal communities, in order to provide better healthcare deliveries.
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http://dx.doi.org/10.1016/j.dsx.2020.06.040 | DOI Listing |
Front Mol Biosci
January 2025
Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Background: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic condition impacting millions of women worldwide. This study sought to identify granulosa cell endoplasmic reticulum stress (GCERS)-related differentially expressed genes (DEGs) between women with PCOS and those without PCOS using bioinformatics and to investigate the related molecular mechanisms.
Methods: Two datasets were downloaded from GEO and analysed using the limma package to identify DEGs in two groups-PCOS and normal granulosa cells.
Indian Dermatol Online J
December 2024
Department of Dermatology, Venereology, and Leprosy, GSL Medical College and General Hospital, Rajahmahendravaram, Andhra Pradesh, India.
Background: Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with metabolic syndrome (MS), such as proinflammatory state, increased oxidative stress, changes in adipokine profile, and coagulation system activation.
Aim And Objectives: To evaluate clinical and laboratory parameters of MS in CSU patients and to assess relationship of MS with duration and severity of CSU, Ig-E, thyroid-stimulating hormone (TSH), C-reactive protein (CRP), and autologous serum skin test (ASST).
Materials And Methods: A hospital-based cross-sectional study was conducted on 131 CSU cases and 131 controls who were age- and sex-matched.
J Tradit Complement Med
November 2024
Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Post-surgical tendon adhesion formation is a frequent clinical complication with limited treatment options. The aim of this study is to investigate safety and efficacy of orally administration of crocin in attenuating post-operative tendon-sheath adhesion bands in an Achilles tendon rat model.
Methods: Structural, mechanical, histological, and biochemical properties of Achilles tendons were analyzed in the presence and absence of crocin.
Front Pharmacol
January 2025
Department of Cardiology, Affiliated Changshu Hospital of Nantong University, Changshu, China.
Objective: This study aims to analyze the adverse drug events (ADEs) associated with tolvaptan in the Food and Drug Administration Adverse Event Reporting System database from the fourth quarter of 2009 to the second quarter of 2024.
Methods: After standardizing the data, various signal detection techniques, including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network, and Multi-Item Gamma Poisson Shrinker, were employed for analysis.
Results: Among the 7,486 ADE reports where tolvaptan was the primary suspected drug, a total of 196 preferred terms were identified, spanning 24 different system organ classes.
Front Endocrinol (Lausanne)
January 2025
Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología, Biotecnología y Genética, Universidad de Buenos Aires, Buenos Aires, Argentina.
Introduction: Polycystic Ovary Syndrome (PCOS) affects 5-20% of reproductive-aged women. Insulin resistance (IR) is common in PCOS with consequent elevated risks of metabolic disorders and cardiovascular mortality. PCOS and obesity are complex conditions associated with Metabolic Syndrome (MS), contributing to cardiovascular disease and type 2 diabetes mellitus (T2D).
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