AI Article Synopsis
- Branched ubiquitin chains, formed by multiple ubiquitin units ligated to different lysine residues, are crucial for various functions in eukaryotic cells.
- Recent research suggests these chains have diverse biological roles, but their precise mechanisms remain largely unclear.
- The article discusses how branched ubiquitin chains function, methods for detecting them, techniques for chemical synthesis, and potential future developments in this emerging area of study.
Article Abstract
Ubiquitin chains with distinct topologies play essential roles in eukaryotic cells. Recently, it was discovered that multiple ubiquitin units can be ligated to more than one lysine residue in the same ubiquitin to form diverse branched ubiquitin chains. Although there is increasing evidence implicating these branched chains in a plethora of biological functions, few mechanistic details have been elucidated. This concept article introduces the function, detection and chemical synthesis of branched ubiquitin chains; and offers some future perspective for this exciting new field.
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| http://dx.doi.org/10.1002/cbic.202000295 | DOI Listing |
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