Elevated platelet lymphocyte ratio is a poor prognostic factor in advanced epithelial ovarian cancer.

J Gynecol Obstet Hum Reprod

Department of Obstetrics and Gynaecology, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.

Published: June 2021

The platelet lymphocyte ratio (PLR) is an important prognostic biomarker in various cancers. The current retrospective study was undertaken to determine the association between PLR and prognosis of advanced epithelial ovarian cancer. We determined the optimal cutoff values of PLR for predicting survival outcomes using the receiver operating characteristic curve analysis. Based on the PLR cutoff values, patients were divided into two groups: <226 and ≥226. Univariate analysis revealed a greater risk of death in the PLR ≥ 226 group than the PLR < 226 group (HR (hazard ratio), 2.7; 95 % CI (confidence interval), 1.3-5.4; P = 0.006). In multivariate analysis, PLR (HR, 1.9; 95 % CI, 1.1-3.6; P = 0.047) significantly affected the overall survival. Our data indicates that PLR can be used as an independent significant prognostic factor in advanced epithelial ovarian cancer.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jogoh.2020.101849DOI Listing

Publication Analysis

Top Keywords

platelet lymphocyte
8
lymphocyte ratio
8
advanced epithelial
8
epithelial ovarian
8
ovarian cancer
8
cutoff values
8
elevated platelet
4
ratio poor
4
poor prognostic
4
prognostic factor
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!